Endocrine Abstracts

Hirata syndrome is a rare cause of spontaneous hypoglycaemia, more prevalent in Japanese population, very infrequent in Caucasian patients. It has been described that it can be triggered by medication with sulfhydryl compounds or α-lipoic acid. A 73-year-old male patient was sent to the Endocrinology Division in December 2015 because he had been presenting with episodes of sweating, palpitations and feeling hungry for 6 months; these symptoms improved when he ate carbohyd...

Introduction: Incidental papillary thyroid carcinoma (PTC) in patients undergoing thyroidectomy for benign multinodular disease is a well-recognised finding. Its true prevalence remains uncertain and shows great variability between studies, ranging from 7–25%. Our purpose was to review the prevalence of PTC in thyroid glands removed for benign nodular disease at a Northern Portuguese tertiary hospital.Methods: From December 2012 to December 2014, th...

Background and aims: Periodontal disease (PD) is a chronic inflammatory condition where the key feature is the alveolar bone loss. Diabetes mellitus is a major risk factor in the occurrence of PD and vitamin D has been found to play a role in the development of diseases such as PD for its immunomoduratory and anti-inflammatory effects. The purpose of this study was to evaluate the relationship between PD and vitamin D levels in type 1 diabetic patients.S...

Bilateral cervical exploration has been the gold standard in parathyroid surgery. Nowadays, the preoperative localization procedures have facilitated the minimally invasive surgery. This study aims to analyze the influence of thyroid disease in Tc99m-sestamibi scintigraphy (MIBI) results.A series of 154 patients with PHP who underwent parathyroidectomy was reviewed. Patients were divided into two groups: group 1 (G1, 58 patients) with thyroid diseases, a...

Background: Primary aldosteronism is a common cause of arterial hypertension, but its underlying molecular mechanisms are unknown. K+ is a key regulator of aldosterone secretion: it interacts with physiological secretagogues of aldosterone as angiotensin II (Ang II) end endothelin-1. In vivo genetic manipulation of a widely distributed class of channels, which generate background or ‘leak’ potassium (K+) currents, the twik-related acid-se...

Background: Correlation between therapy with interferons, thyroid autoimmunity and dysfunction is widely reported. Currently we used two different pegilated-interferons (α-2a, α-2b).Aim: Evaluate a probable different behaviour of two PEG-IFN responsible of thyroid abnormalities.Patients and methods: We observed 236 consecutive naïve-patients with HCV-related chronic-disease undergoing a treatment with antiviral thera...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Introduction: Immunotherapy has demonstrated a key role in the current individualized treatment of multiple neoplasms, with adverse events related to the endocrine. Thyroid dysfunction is the most frequent reported endocrine event during treatment with pembrolizumab, being autoimmune diabetes an extremely rare adverse effect.Case Report: We present a case of a 72-year-old man with a progressing urothelial bladder carcinoma (stage IIIB), under treatment w...

Objective: AGEs, compounds formed by the transformation of proteins, are increased in conditions of oxidative stress and promote inflammation by interacting with their receptor (RAGE) on cell membrane. By contrast, the soluble receptor for AGE (sRAGE), that is proteolytically cleaved from cell surface receptor via matrix metalloproteinases, sequester RAGE ligands and act as a cytoprotective and anti-inflammatory agent. AGEs/sRAGE interaction play a role in the pathogenesis of ...

Introduction: Gestational diabetes (GD) is associated with a significantly higher risk of perinatal complications. It has been suggested that third-trimester (3thT) foetal abdominal circumference (fAC) determination is an important predictor of macrossomia and large for gestational age (LGA).Aims: The purpose of this study was to evaluate the association between the 3thT fAC percentile with birthweight (BW) and adverse neonatal outc...